Base by Base
439: Coembedding Sequence and Structure: CLSS Maps the Protein Universe
23:08
Longo LM et al., PNAS - This episode summarizes a PNAS study introducing CLSS, a contrastive two-tower protein language model that coembeds domain sequences, structures, and subsequences into a shared 32-dimensional latent space. Trained self-supervised on one million ECOD domains, CLSS aligns sequence and structure modalities, yields compact embeddings that recapitulate ECOD and CATH…