Decoding Health
Why Natural GLP-1 Disappears So Fast: DPP-4, Half-Life, and How Ozempic-Style Drugs Are Engineered
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GLP-1 is a gut-derived hormone designed to signal the pancreas to produce insulin—but in its natural form, it’s notoriously short-lived. In this Decoding Health segment, we break down why endogenous GLP-1 has an ultra-short half-life (about three minutes), and how the enzyme DPP-4 rapidly “clips” incretin hormones by targeting specific amino acids near the…