Castuner

Science TLDR

Raymond Ruff

Ten-minute paper summaries for scientists and experts.

Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week.

Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype.

Feedback and paper suggestions: [email protected]

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Episodes

100 episodes

  1. Episode 98: Biomolecular design through latent reasoning with RFD4-Proteina 10:36
  2. Episode 97: Aberrant expression of HERV-K envelope in lymphoma represents an opportunity for novel treatments. 10:55
  3. Episode 96: Reddit Trending — The dietary fibre content of fruit and vegetable kitchen preparation waste and UK consumers’ dietary fibre-related attitudes regarding its consumption 10:33
  4. Episode 95: Shared α-helix chimeraffibodies enable linker-free bispecific protein design 11:05
  5. Episode 94: Reddit Trending — The Effect of Deactivating Facebook and Instagram on Users’ Emotional State 10:12
  6. Episode 93: Reddit Trending — Associations of food processing and dietary risk factors with colorectal cancer incidence in the NIH-AARP Diet and Health Study: A cohort study 11:20
  7. Episode 92: Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism 11:52
  8. Episode 91: Reddit Trending — “It’s Like You’re Trying to Defuse a Bomb”: Fear, Responsibility, and Shame in Young Men’s Sexual Lives 10:24
  9. Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition 9:29
  10. Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse 9:32
  11. Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation 11:30
  12. Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024? 10:53
  13. Episode 86: Specific targeting of MR1-antigen complexes using nanobodies 11:03
  14. Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits 10:44
  15. Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States 10:46
  16. Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex 11:24
  17. Episode 82: Reddit Trending — Substantial under-detection of human rabies cases in the United States 10:51
  18. Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability 23:28
  19. Episode 80: Reddit Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata 15:03
  20. Episode 79: Reddit Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study 21:41
  21. Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation 21:40
  22. Episode 77: Reddit Trending — People prefer to negotiate with women, even when outcomes are identical and gender is unknown 19:30
  23. Episode 76: Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors 20:27
  24. Episode 75: Reddit Trending — A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone 18:40
  25. Episode 74: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow 11:56
  26. Episode 73: Reddit Trending — Work from Home and Disability Employment 22:40
  27. Episode 72: From free speech advocates to critics: The Trump administration’s new rhetoric promotes support for censorship among Trump voters 19:12
  28. Episode 71: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial 22:09
  29. Episode 70: Language Modeling Materializes a World Model of Protein Biology 19:34
  30. Episode 69: Novel bispecific T-cell engagers overcoming acquired EGFR resistance 21:36
  31. Episode 68: The lived experience of rejection sensitivity in ADHD - A qualitative exploration 23:48
  32. Episode 67: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery 21:09
  33. Episode 66: The political polarization of health outcomes in the USA 19:57
  34. Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager 21:34
  35. Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero 23:43
  36. Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies 21:28
  37. Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study 23:16
  38. Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology 20:57
  39. Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies 22:39
  40. A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity 11:55
  41. Language models cannot reliably distinguish belief from knowledge and fact 14:45
  42. Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment 19:20
  43. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade 16:37
  44. Guidelines for Early Food Introduction and Patterns of Food Allergy 14:34
  45. Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design 15:29
  46. A genetic common factor underlying self-reported math ability and highest math class taken 16:07
  47. Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition 13:57
  48. The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple? 17:02
  49. Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy 19:23
  50. Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy 20:18