Tiny Matters

Giant viruses: How these amoeba-infecting behemoths are rewriting the rules of virology

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Scientists spent decades searching for viruses by filtering out anything too large to be one. That strategy seemed to work well... until it didn't. When researchers discovered a microbe living inside an amoeba that looked like a bacterium but behaved like something else entirely, they uncovered a hidden world of giant viruses with massive genomes, unusual genes, and even their own viral…